5.1. Intraoperative use and needling bleb revision with mitomycin C Intraoperative use and needling bleb revision with mitomycin C
نویسنده
چکیده
MMC when applied topically or injected subconjunctivally, prevents proliferation of fibroblasts within the subconjunctival space and tenon’s capsule. It also has a lethal effect on vascular endothelial cells. A single application of MMC can cause localized, irreversible inhibition of both fibroblasts and vascular endothelial cells. MMC is estimated to be 100 times more potent than 5-FU in fibroblast inhibition.
منابع مشابه
Needling augmented with topical application of mitomycin C for management of bleb failure.
PURPOSE To study the effect of topical application of mitomycin C on enhancing the efficacy of needling in the management of bleb failure. PATIENTS AND METHODS Thirty-six eyes of 32 consecutive patients with an intraocular pressure over 21 mmHg, without bleb or with a thick, flat bleb after the second postoperative month after trabeculectomy, were included in the study. Needling with mitomyci...
متن کاملEarly transconjunctival needling revision with 5-fluorouracil versus medical treatment in encapsulated blebs: a 12-month prospective study
OBJECTIVE To compare the efficacy of transconjunctival needling revision with 5-fluorouracil versus medical treatment in glaucomatous eyes with uncontrolled intraocular pressure due to encapsulated bleb after trabeculectomy. METHODS Prospective, randomized, interventional study. A total of 40 eyes in 39 patients with elevated intraocular pressure and encapsulated blebs diagnosed at a maximum ...
متن کاملRevision of encapsulated blebs after trabeculectomy: Long-term comparison of standard bleb needling and modified needling procedure combined with transconjunctival scleral flap sutures
PURPOSE To compare two surgical approaches for treating encapsulated blebs after trabeculectomy with mitomycin C, in terms of the development of intraocular pressure and progression of glaucoma in a long-term follow up: 1. bleb needling alone vs. 2. a combined approach of needling with additional transconjunctival scleral flap sutures, to prevent early ocular hypotony. METHODS Forty-six patie...
متن کاملIntraoperative Optical Coherence Tomography Guided Bleb Needling
Two patients with history of trabeculectomy presented with uncontrolled intraocular pressure (IOP) postoperatively. The first patient had a flat and vasularized bleb 10 weeks after the surgery, and the second subject developed encapsulated bleb 3 months postoperatively. Both patients were taken to the operating room and intraoperative optical coherence tomography (OCT) guided bleb needling was ...
متن کاملThe relationship of bleb morphology and the outcome of needle revision with 5-fluorouracil in failing filtering bleb
To investigate the risk factors for failure of needling revision with 5-fluorouracil (5-FU) and to identify the correlation of outcomes of needling revision and the morphological features of dysfunctional filtration blebs using Moorfields bleb grading system.This retrospective, nonrandomized, comparative case-control study included 41 consecutive patients (41 eyes) who underwent 5-FU needling r...
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تاریخ انتشار 2015